Description

Description

Gravibinan (250/5mg) 2ml Ampoule Injection is a hormonal combination medicine manufactured by Bayer Pakistan, containing Hydroxyprogesterone Caproate and Estradiol Valerate. This formulation pairs a progestin with an estrogen to support hormonal balance during pregnancy and to address certain gynecological conditions. Hydroxyprogesterone Caproate works by supplementing the body’s natural progesterone levels, which plays a key role in maintaining a stable uterine environment, while Estradiol Valerate contributes estrogen support that complements the progestin’s action. This injection is primarily used under close medical supervision, most often in women who have a history of preterm delivery or who require hormonal support for specific reproductive health concerns.

Ingredients

Each 2ml ampoule of Gravibinan contains Hydroxyprogesterone Caproate 250mg and Estradiol Valerate 5mg as its active hormonal components, formulated in an oily injectable base suitable for intramuscular administration.

Dosage Form

Gravibinan is supplied as an oil-based solution for injection, packaged in a 2ml glass ampoule. It is intended for intramuscular use only and is prepared for single-dose administration by a trained healthcare provider.

Uses

Gravibinan is primarily prescribed to help prevent preterm birth in pregnant women who have a documented history of premature delivery or who are considered at elevated risk for it. Beyond pregnancy support, it may also be used by physicians to manage certain gynecological disorders where progestin and estrogen supplementation is clinically appropriate. Because it directly affects hormonal balance, its use is always tailored to the individual patient’s medical history and current condition.

How to Use

Gravibinan is administered only by a doctor or qualified healthcare professional as a deep intramuscular injection, typically into the upper outer area of the buttock. When used for preterm birth prevention, treatment commonly begins between the 16th and 20th week of pregnancy and continues on a weekly schedule, with dosing spaced roughly seven days apart, until around the 37th week or delivery, whichever comes first. The exact schedule, dose, and duration are determined by the prescribing physician based on the patient’s individual pregnancy profile, and this medicine should never be self-administered or adjusted without medical guidance.

Side Effects

As with most hormonal injections, Gravibinan may cause side effects in some patients. Commonly reported effects include pain, swelling, or irritation at the injection site, mild nausea, headache, and breast tenderness. Less common but more serious effects can include mood changes, fluid retention, changes in blood pressure, and, rarely, blood clotting disorders such as deep vein thrombosis. Patients with a personal or family history of clotting problems, heart disease, or hormone-sensitive conditions should discuss these risks thoroughly with their doctor before starting treatment. Any unusual swelling, chest pain, severe headache, or vision changes should be reported to a healthcare provider immediately.

Pregnancy & Breastfeeding

Gravibinan is specifically used during pregnancy under medical supervision, most often to help reduce the risk of preterm delivery in women with a prior history of the condition. Its use must always be guided and monitored by an obstetrician or qualified physician, who will weigh the benefits against any individual risk factors. Regarding breastfeeding, hormonal medicines of this type may pass into breast milk, so nursing mothers should consult their doctor before use, as the physician may recommend an alternative approach depending on the clinical situation.

Storage Instructions

Store Gravibinan ampoules at room temperature, away from direct sunlight, excessive heat, and moisture, generally within the range of 15–30°C. Keep the ampoule in its original packaging until it is ready to be used, and store it safely out of the reach of children and pets. Each ampoule is intended for single use only, and any unused portion should be discarded rather than saved for later use. Do not use the product if the solution appears discolored or contains visible particles, or if the ampoule shows any signs of damage.

FAQs

What is Gravibinan mainly used for?
It is mainly used to help prevent preterm birth in pregnant women with a history of premature delivery, and occasionally for certain gynecological conditions.

Can Gravibinan be self-administered at home?
No, it must be given by a doctor or trained healthcare professional as an intramuscular injection.

Is Gravibinan safe throughout pregnancy?
Its use is closely monitored by a physician and is typically started and continued within a specific gestational window determined by the doctor based on the patient’s condition.

Can breastfeeding mothers use Gravibinan?
This should only be decided in consultation with a doctor, as hormonal components may pass into breast milk.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.