Description

Description

Olesta AM (5/20mg) is a combination antihypertensive medicine manufactured by Searle, formulated with Amlodipine and Olmesartan Medoxomil as its active ingredients. It brings together a calcium channel blocker and an angiotensin II receptor blocker in a single tablet, offering dual-action blood pressure control for patients who need combination therapy. This pack contains 20 tablets, combining 5mg of amlodipine with 20mg of olmesartan. Olesta AM is commonly used for managing high blood pressure and preventing certain types of chest pain, working by relaxing blood vessels through two complementary mechanisms to support smoother blood flow and reduced strain on the heart.

Ingredients

Each Olesta AM tablet contains Amlodipine 5mg and Olmesartan Medoxomil 20mg. Amlodipine, a calcium channel blocker, works by selectively inhibiting calcium ion influx across cell membranes, which relaxes vascular smooth muscle and leads to vasodilation, reducing peripheral resistance and blood pressure. Olmesartan Medoxomil, an angiotensin II receptor blocker, prevents angiotensin II from binding to its receptors, inhibiting its vessel-constricting effects and further lowering blood pressure. Together, these two mechanisms provide a more effective and comprehensive blood pressure-lowering effect than either medicine alone. The tablet also contains standard inactive excipients used for formulation and stability.

Dosage Form

Olesta AM is available as an oral, film-coated tablet, supplied in a pack of 20 tablets. It is intended for once-daily administration, providing consistent 24-hour blood pressure control for patients requiring dual combination therapy.

Uses

Olesta AM is primarily used to treat essential hypertension in adults who require combination therapy for effective blood pressure control. It is also used to help prevent certain types of chest pain, known as angina, related to reduced blood flow to the heart. By combining a calcium channel blocker with an angiotensin receptor blocker, Olesta AM offers superior blood pressure control compared to single-agent therapy, helping reduce the risk of stroke, heart attack, and kidney complications associated with uncontrolled hypertension.

How to Use

Olesta AM should be taken exactly as prescribed by a physician, generally as one tablet once daily, with or without food. The tablet should be swallowed whole with a glass of water, and taking it at the same time each day supports more consistent blood pressure control. Your doctor may suggest taking the first dose before bedtime, as it can cause dizziness initially; subsequent doses can typically be taken at any convenient time of day. If you are also taking cholesterol-lowering resins such as cholestyramine, it’s advised to take this medicine at least four hours apart from those medications.

Side Effects

Common side effects of Olesta AM include inflammation of the nose and throat, dizziness, nausea, and stomach discomfort. Swelling in the feet, ankles, or lower legs has also been reported, which is a known effect of the calcium channel blocker component. Because Olesta AM can cause dizziness, especially with the first dose, caution is advised when driving or operating machinery until its effects are known. Periodic monitoring of potassium levels and kidney function is recommended, particularly with long-term use. Any severe or persistent symptoms should be reported to a doctor promptly.

Pregnancy & Breastfeeding

Olesta AM should not be used during pregnancy, as angiotensin receptor blockers like olmesartan carry known risks to fetal development, particularly during the second and third trimesters. Women who are pregnant or planning pregnancy should consult their doctor about safer alternatives. Breastfeeding mothers should also seek medical advice before using this medicine, as its safety during lactation has not been clearly established.

Storage Instructions

Store Olesta AM tablets below 30 degrees Celsius, in a cool, dry place, away from direct sunlight and moisture. Keep the tablets in their original packaging until ready for use to protect them from environmental exposure. Store the medicine out of reach of children and pets, and do not use tablets beyond their printed expiry date.

FAQS

Why does the first dose of Olesta AM sometimes cause dizziness?
The initial dose can lower blood pressure more noticeably as the body adjusts, which is why doctors often recommend taking it before bedtime initially.

Can Olesta AM be taken with grapefruit juice?
It’s best to limit grapefruit juice, as it may increase amlodipine levels in the blood and affect the medicine’s action.

Is regular monitoring needed while taking Olesta AM?
Yes, periodic checks of blood pressure, kidney function, and potassium levels are generally recommended during treatment.

Can Olesta AM be used to prevent chest pain?
Yes, it is also used to help prevent certain types of angina related to reduced blood flow to the heart.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.