Description

Description

Olesta AM (5/40mg) is a combination antihypertensive medicine manufactured by Searle, formulated with Amlodipine and Olmesartan Medoxomil as its active ingredients. This particular strength contains a higher dose of olmesartan compared to the standard formulation, making it suitable for patients who require stronger angiotensin receptor blocking action alongside the calcium channel blocking effect of amlodipine. This pack contains 20 tablets, combining 5mg of amlodipine with 40mg of olmesartan. Olesta AM (5/40mg) is commonly used for managing high blood pressure that requires more intensive dual combination therapy for effective control.

Ingredients

Each Olesta AM tablet in this strength contains Amlodipine 5mg and Olmesartan Medoxomil 40mg. Amlodipine, a calcium channel blocker, works by selectively inhibiting calcium ion influx across cell membranes, relaxing vascular smooth muscle and reducing peripheral resistance. Olmesartan Medoxomil, present here at a higher dose, works as an angiotensin II receptor blocker, preventing angiotensin II from binding to its receptors and inhibiting its vasoconstrictor and aldosterone-secreting effects, which leads to more pronounced blood pressure reduction. Together, these two mechanisms provide a stronger combined effect for patients requiring more intensive hypertension management. The tablet also contains standard inactive excipients used for formulation and stability.

Dosage Form

Olesta AM is available as an oral, film-coated tablet, supplied in a pack of 20 tablets. This higher-strength formulation is intended for once-daily administration in patients who need a more intensive level of blood pressure control than the standard dose combination provides.

Uses

Olesta AM (5/40mg) is primarily used to treat essential hypertension in adults who require stronger combination therapy for adequate blood pressure control, particularly those who haven’t achieved sufficient results on lower-dose combinations. By combining a calcium channel blocker with a higher-strength angiotensin receptor blocker, this formulation supports more effective management of resistant or harder-to-control high blood pressure, helping reduce the long-term risk of stroke, heart attack, and kidney complications.

How to Use

Olesta AM should be taken exactly as prescribed by a physician, generally as one tablet once daily, with or without food. The tablet should be swallowed whole with a glass of water, and taking it at the same time each day supports more consistent blood pressure control. Your doctor may suggest taking the first dose before bedtime, as it can cause dizziness initially. If you are also taking cholesterol-lowering resins such as cholestyramine, it’s advised to take this medicine at least four hours apart from those medications. Given the higher strength, dosage should never be self-adjusted.

Side Effects

Because this strength contains a higher olmesartan dose, patients may be somewhat more likely to experience side effects such as dizziness, inflammation of the nose and throat, and nausea or stomach discomfort. Swelling in the feet, ankles, or lower legs has also been reported, related to the amlodipine component. Because dizziness can occur, particularly with the first dose, caution is advised when driving or operating machinery. Periodic monitoring of potassium levels and kidney function is especially important at this strength during long-term use. Any severe or persistent symptoms should be reported to a doctor promptly.

Pregnancy & Breastfeeding

Olesta AM should not be used during pregnancy, as angiotensin receptor blockers like olmesartan carry known risks to fetal development, particularly during the second and third trimesters. Women who are pregnant or planning pregnancy should consult their doctor about safer alternatives. Breastfeeding mothers should also seek medical advice before using this medicine, especially at this higher strength, as its safety during lactation has not been clearly established.

Storage Instructions

Store Olesta AM tablets below 30 degrees Celsius, in a cool, dry place, away from direct sunlight and moisture. Keep the tablets in their original packaging until ready for use to protect them from environmental exposure. Store the medicine out of reach of children and pets, and do not use tablets beyond their printed expiry date.

FAQS

How does this strength differ from the standard Olesta AM formulation?
It contains a higher olmesartan dose (40mg instead of 20mg), intended for patients needing stronger blood pressure control.

Is this formulation suitable for first-time hypertension treatment?
No, it is typically prescribed for patients who require stronger combination therapy after trying lower-dose options.

Can Olesta AM 5/40mg be combined with other blood pressure medicines?
Yes, but such combinations should always be reviewed by a doctor to avoid potential interactions.

How often should kidney function be monitored on this dose?
Your doctor will typically recommend periodic kidney function and electrolyte testing throughout treatment at this strength.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.