Description

Description

Sitaphage XR (50/1000mg) is a prescription combination medicine used in the management of type 2 diabetes mellitus in adults. This extended-release formulation pairs sitagliptin with a higher strength of metformin in a single tablet, designed to release its active ingredients gradually over time and support steady blood sugar control with a convenient once-daily dosing schedule. It is typically prescribed for patients who require a stronger metformin dose alongside sitagliptin, whether they are stepping up from a lower strength or transitioning from separate immediate-release medicines to a more manageable combined regimen. This pack contains 14 tablets, offering a short-term supply for starting or continuing a prescribed diabetes treatment plan.

Ingredients

Each Sitaphage XR 50/1000mg tablet contains sitagliptin 50 mg, present as sitagliptin phosphate monohydrate, together with metformin hydrochloride 1000 mg in an extended-release form. Sitagliptin belongs to the DPP-4 inhibitor class of medicines, while metformin belongs to the biguanide class. The extended-release technology used in the metformin component allows the medicine to be absorbed gradually over several hours, which helps maintain more even blood sugar levels throughout the day and generally reduces the digestive side effects associated with immediate-release metformin, even at this higher strength.

Dosage Form

Sitaphage XR is manufactured as a film-coated, extended-release oral tablet, meant to be swallowed whole with water. It should never be crushed, split, or chewed, as doing so would interfere with the extended-release mechanism and could cause the medicine to be released too quickly, raising the risk of side effects.

Uses

Sitaphage XR 50/1000mg is used for the treatment of type 2 diabetes in adults, particularly those who need a higher metformin dose combined with sitagliptin in a once-daily formulation. It works by helping the pancreas release insulin more effectively after meals, reducing the amount of sugar produced by the liver, and improving the body’s overall sensitivity to insulin. This strength is often prescribed for patients already taking higher daily doses of metformin who need sitagliptin added to their treatment, or for those being switched from the immediate-release combination to the extended-release schedule for greater convenience. It is not intended for type 1 diabetes or for treating diabetic ketoacidosis, and it works best as part of a broader plan that includes a proper diet and regular exercise.

How to Use

Sitaphage XR 50/1000mg is generally taken once daily, most often with the evening meal, though the exact dose and timing should always follow a doctor’s specific instructions, since this depends on the patient’s current metformin regimen, kidney function, and overall response to treatment. The tablet must be swallowed whole and never broken apart. If a dose is missed, it should be taken as soon as remembered, unless it is nearly time for the next scheduled dose, in which case the missed dose should be skipped rather than doubled. Taking the medicine at a consistent time each day helps support the steady blood sugar control this formulation is designed to provide.

Side Effects

Side effects of Sitaphage XR 50/1000mg are generally similar to those seen with other sitagliptin and metformin combinations, though gastrointestinal effects may be somewhat more noticeable given the higher metformin content. Commonly reported effects include nausea, diarrhea, upper abdominal discomfort, and occasionally a mild decrease in blood glucose. Some patients may also notice drowsiness or digestive changes, particularly when first starting the medicine or after a dose increase. More serious but rare effects can include signs of pancreatitis, lactic acidosis, or allergic reactions such as swelling or skin rash, and any of these should prompt immediate medical attention. Alcohol is best avoided while taking this medicine, as it can increase the risk of lactic acidosis associated with metformin.

Pregnancy & Breastfeeding

Sitaphage XR is generally not recommended during pregnancy, as its safety in pregnant women has not been firmly established, and insulin is usually the preferred option for managing blood sugar during this time. It is also advisable to avoid this medicine while breastfeeding unless a doctor has specifically approved its use, since it is not fully known how the ingredients transfer into breast milk. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss their diabetes management options with their doctor before starting or continuing this medication.

Storage Instructions

Sitaphage XR tablets should be stored at room temperature, away from direct sunlight, heat, and moisture. They should remain in their original packaging until ready for use and should be kept safely out of the reach of children. The tablets should not be used after their printed expiry date has passed.

FAQs

Is a prescription required to buy Sitaphage XR 50/1000mg? Yes, this is a prescription-only medicine and should not be started, stopped, or adjusted without a doctor’s guidance. How is the 50/1000mg strength different from the 50/500mg version? The sitagliptin dose stays the same, but the metformin content is doubled, making this strength suitable for patients who require a higher total daily metformin dose. Can Sitaphage XR tablets be crushed or split? No, they should always be swallowed whole, since crushing or splitting disrupts the extended-release mechanism and can affect how the medicine works. What should be done if a dose is missed? Take it as soon as it is remembered, unless it is close to the time of the next dose, in which case the missed dose should simply be skipped.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.