Description

Description

Sitaphage XR (100/1000mg) is a prescription combination medicine used in the management of type 2 diabetes mellitus in adults. This extended-release formulation combines a full dose of sitagliptin with a high strength of metformin in a single tablet, designed to release its active ingredients gradually and support steady blood sugar control with a convenient once-daily dosing schedule. It is typically prescribed for patients who require the maximum recommended daily dose of sitagliptin alongside a higher metformin dose, whether they are starting combination therapy fresh, stepping up from a lower strength, or transitioning from separate immediate-release medicines to a more manageable once-daily regimen. This pack contains 14 tablets, offering a short-term supply for starting or continuing a prescribed diabetes treatment plan.

Ingredients

Each Sitaphage XR 100/1000mg tablet contains sitagliptin 100 mg, present as sitagliptin phosphate monohydrate, together with metformin hydrochloride 1000 mg in an extended-release form. Sitagliptin belongs to the DPP-4 inhibitor class of medicines, while metformin belongs to the biguanide class. This strength delivers the full recommended daily dose of sitagliptin in a single tablet, paired with the extended-release metformin technology that allows for gradual absorption over several hours, helping to maintain more even blood sugar levels and generally reducing the digestive side effects associated with immediate-release metformin.

Dosage Form

Sitaphage XR is manufactured as a film-coated, extended-release oral tablet, meant to be swallowed whole with water. It should never be crushed, split, or chewed, as doing so would interfere with the extended-release mechanism and could cause the medicine to be released too quickly, increasing the risk of side effects.

Uses

Sitaphage XR 100/1000mg is used for the treatment of type 2 diabetes in adults, particularly those who need the full daily sitagliptin dose combined with a higher metformin dose in a once-daily formulation. It works by helping the pancreas release insulin more effectively after meals, reducing the amount of sugar produced by the liver, and improving the body’s overall sensitivity to insulin. This strength is often prescribed for patients not previously on metformin who are starting combination therapy, or for those already taking higher doses of metformin who need the full sitagliptin dose added to their treatment. It is not intended for type 1 diabetes or for treating diabetic ketoacidosis, and it works best as part of a broader plan that includes a proper diet and regular exercise.

How to Use

Sitaphage XR 100/1000mg is generally taken once daily, most often with the evening meal, though the exact dose and timing should always follow a doctor’s specific instructions, since this depends on the patient’s current diabetes treatment, kidney function, and overall response. The tablet must be swallowed whole and never broken apart. If a dose is missed, it should be taken as soon as remembered, unless it is nearly time for the next scheduled dose, in which case the missed dose should be skipped rather than doubled. Taking the medicine at a consistent time each day helps support the steady blood sugar control this formulation is designed to provide.

Side Effects

Side effects of Sitaphage XR 100/1000mg are generally similar to those seen with other sitagliptin and metformin combinations, though gastrointestinal effects may be more noticeable given the higher combined strength. Commonly reported effects include nausea, diarrhea, upper abdominal discomfort, and occasionally a mild decrease in blood glucose. Some patients may also notice drowsiness or digestive changes, particularly when first starting the medicine. More serious but rare effects can include signs of pancreatitis, lactic acidosis, or allergic reactions such as swelling or skin rash, and any of these should prompt immediate medical attention. Alcohol is best avoided while taking this medicine, as it can increase the risk of lactic acidosis associated with metformin.

Pregnancy & Breastfeeding

Sitaphage XR is generally not recommended during pregnancy, as its safety in pregnant women has not been firmly established, and insulin is usually the preferred option for managing blood sugar during this time. It is also advisable to avoid this medicine while breastfeeding unless a doctor has specifically approved its use, since it is not fully known how the ingredients transfer into breast milk. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss their diabetes management options with their doctor before starting or continuing this medication.

Storage Instructions

Sitaphage XR tablets should be stored at room temperature, away from direct sunlight, heat, and moisture. They should remain in their original packaging until ready for use and should be kept safely out of the reach of children. The tablets should not be used after their printed expiry date has passed.

FAQs

Is a prescription required to buy Sitaphage XR 100/1000mg? Yes, this is a prescription-only medicine and should not be started, stopped, or adjusted without a doctor’s guidance. How is the 100/1000mg strength different from the lower strengths? This version contains the full recommended daily dose of sitagliptin along with the higher metformin strength, making it suitable for patients not previously on metformin therapy or those needing the maximum sitagliptin dose. Can Sitaphage XR tablets be crushed or split? No, they should always be swallowed whole, since crushing or splitting disrupts the extended-release mechanism and can affect how the medicine works. What should be done if a dose is missed? Take it as soon as it is remembered, unless it is close to the time of the next dose, in which case the missed dose should simply be skipped.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.