Description

Description

Jardy-Met XR 12.5/1000mg is a once-daily, extended-release combination tablet designed for patients who need a higher SGLT2 dose alongside the maximum available extended-release Metformin content, packaged 14 tablets to a pack. It is built with an outer layer of immediate-release Empagliflozin surrounding an extended-release Metformin core that releases its dose gradually over several hours. Empagliflozin works as an SGLT2 inhibitor, prompting the kidneys to clear excess glucose through urine, while the extended-release Metformin steadily lowers the liver’s glucose output and improves how effectively the body responds to its own insulin throughout the day. This strength is typically used once a patient has already shown good tolerance to both components individually, allowing a stronger combined effect to be delivered through one convenient once-daily tablet.

Ingredients

Each Jardy-Met XR 12.5/1000mg tablet contains:

• Empagliflozin – 12.5 mg (immediate-release outer layer)
• Metformin Hydrochloride – 1000 mg (extended-release core)

The tablet also contains standard inactive excipients that form the extended-release matrix and outer film coating, which regulate the gradual release of Metformin and support easy swallowing, without any therapeutic effect of their own.

Dosage Form

Jardy-Met XR 12.5/1000mg is manufactured as an extended-release, film-coated oral tablet, supplied 14 tablets per pack, intended for once-daily oral use.

Uses

Jardy-Met XR 12.5/1000mg is generally prescribed to:

• Improve blood glucose control in adults with type 2 diabetes mellitus who need a higher Empagliflozin dose combined with extended-release Metformin
• Allow patients already stabilized on Empagliflozin 12.5mg and Metformin 1000mg, taken separately or in immediate-release form, to transition to a more convenient once-daily extended-release tablet
• Support broader long-term diabetes management, including potential cardiovascular and kidney-related benefits, when paired with an appropriate diet and consistent physical activity

It is not intended for people with type 1 diabetes or for the management of diabetic ketoacidosis.

How to Use

The following points are general guidance only — always follow the specific instructions given by your prescribing doctor:

• Take the tablet once daily, generally with the evening meal, as directed by your doctor.
• Swallow the tablet whole with a glass of water; because it is extended-release, never crush, split, or chew it, as this can cause the full dose to release too quickly.
• It’s normal to occasionally notice the outer tablet shell in the stool, since this part of the extended-release matrix is not fully absorbed; this does not mean the medicine was ineffective.
• Maintain a consistent daily timing to help support stable blood sugar management.
• Attend recommended blood tests, including kidney function monitoring, since safe use at this strength depends on adequate kidney health, particularly given the higher Empagliflozin dose.

Side Effects

Side effects can vary between individuals, but commonly reported ones with this combination include:

• Nausea, diarrhea, or general stomach discomfort, typically milder than with immediate-release metformin, especially once the body adjusts
• Reduced appetite or a metallic taste in the mouth
• Increased urinary frequency, often more noticeable at this higher Empagliflozin dose
• Mild dehydration or increased thirst
• Urinary tract or genital yeast infections

Less commonly, more serious concerns can occur, including a marked drop in blood pressure, lactic acidosis (a rare but serious risk associated with metformin, more likely with reduced kidney or liver function), or symptoms suggesting diabetic ketoacidosis such as persistent nausea, vomiting, or abdominal pain even when blood sugar readings appear normal. Any of these symptoms warrant urgent medical attention. This overview is not exhaustive, so any unusual or persistent symptom should be discussed with a doctor or pharmacist.

Pregnancy & Breastfeeding

Jardy-Met XR 12.5/1000mg is generally not recommended during pregnancy, since the Empagliflozin component may affect fetal kidney development, particularly in later stages of pregnancy, and diabetes management in pregnant women is typically handled through alternative approved treatments under specialist care. It is also generally not advised during breastfeeding. Women who are pregnant, planning to become pregnant, or currently breastfeeding should speak with their doctor before starting or continuing this medication.

Storage Instructions

• Store Jardy-Met XR 12.5/1000mg tablets at room temperature, ideally below 25°C, away from direct sunlight, heat, and excess humidity.
• Keep tablets in their original blister packaging until they are needed.
• Store out of reach of children.
• Do not use tablets past their printed expiry date, and dispose of unused medicine responsibly rather than through household waste.

FAQS

How does the 12.5/1000mg XR strength differ from the 10/1000mg version?
Both contain the same extended-release Metformin dose, but this version has a higher Empagliflozin strength, generally chosen when a stronger SGLT2 effect is needed for adequate glycemic control.

Why can’t I crush or split this tablet?
Doing so would disrupt the extended-release mechanism, releasing the full metformin dose at once instead of gradually, which increases the risk of digestive side effects.

Will this dose increase my risk of dehydration?
Because the Empagliflozin dose is higher, some patients notice more fluid loss through increased urination, so maintaining adequate hydration is generally advised.

Can I switch straight to Jardy-Met XR 12.5/1000mg from a lower XR strength?
No, dose changes should always be made gradually and only under a doctor’s supervision, based on your blood sugar response and tolerance.

Does this strength require more frequent doctor visits?
Your doctor may schedule closer monitoring of kidney function and blood pressure at this dose, especially during the initial adjustment period.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.