Description

Description

Ampiclox (500mg) is a higher-strength combination antibiotic capsule containing Ampicillin and Cloxacillin, manufactured by GlaxoSmithKline (GSK) Pakistan, generally used for more significant bacterial infections or when a stronger combined dose is needed. As with the 250mg strength, this pairing brings together two penicillin-group antibiotics that work through complementary mechanisms — Ampicillin acts against a broad range of gram-positive and gram-negative bacteria, while Cloxacillin adds effectiveness against certain penicillin-resistant staphylococcal bacteria by resisting the beta-lactamase enzyme some bacteria use to defend themselves. This combination is commonly used for infections of the respiratory tract, skin, ear, throat, urinary tract, and certain soft tissue and bone infections. The pack contains 100 capsules and is generally intended for extended treatment courses or pharmacy and clinical supply, as directed by a doctor.

Ingredients

Each Ampiclox (500mg) capsule contains Ampicillin (as ampicillin trihydrate) 250mg and Cloxacillin (as cloxacillin sodium) 250mg, together totaling 500mg of combined active ingredients, along with standard pharmaceutical excipients that make up the capsule’s shell and filling.

Dosage Form

This medicine is supplied as an oral capsule, meant to be swallowed with water, generally with or without food, though your doctor’s specific instructions should be followed for best absorption.

Uses

Ampiclox (500mg) is used to treat a wide variety of bacterial infections affecting the respiratory tract, skin, ear, throat, urinary tract, stomach, and intestines, particularly when a higher-strength combined dose is needed for effective treatment. Ampicillin interferes with bacterial cell wall synthesis by binding to penicillin-binding proteins, preventing bacteria from forming the walls they need to survive, while Cloxacillin adds resistance against certain bacteria capable of destroying standard penicillins. Together, this stronger combination is effective against a broad spectrum of gram-positive and gram-negative bacteria, making it a versatile option for more significant bacterial infections.

How to Use

Ampiclox should be taken exactly as prescribed by a doctor, typically several times daily, with or without food. The specific dosage, timing, and duration should always be determined by your doctor based on your age, condition, and symptoms. It’s important to complete the full prescribed course, even if symptoms improve before the course is finished, since stopping early can allow the infection to persist or contribute to antibiotic resistance.

Side Effects

Side effects from Ampiclox are generally uncommon when the medicine is used as directed, but can include mild digestive upset, nausea, or diarrhea. Skin rash has also been reported in some patients. Any signs of a more serious allergic reaction, such as swelling of the face or throat, difficulty breathing, or widespread rash, should be treated as a medical emergency and require immediate attention. This medicine should not be taken alongside tetracycline antibiotics, and caution is advised if the patient has recently received a vaccination or has mononucleosis (glandular fever).

Pregnancy & Breastfeeding

Anyone who is pregnant or breastfeeding should consult their doctor before using Ampiclox, since the appropriateness of this combination during these periods depends on individual circumstances and the specific infection being treated. A healthcare provider can help determine whether this medicine is suitable or whether an alternative treatment might be preferred.

Storage Instructions

Store Ampiclox capsules in a cool, dry place, away from direct light and heat. Keep the medicine safely out of reach of children and pets. Any expired or unused capsules should be disposed of properly rather than kept or used past their intended shelf life.

FAQs

Why would a doctor prescribe 500mg instead of 250mg?
The higher strength is generally used for more significant bacterial infections or when a stronger combined dose is needed to achieve effective treatment.

Can this medicine be taken on an empty stomach?
It can generally be taken with or without food, but following your doctor’s specific instructions helps ensure the best absorption and effectiveness.

Should I avoid any other medicines while taking Ampiclox?
Yes, tetracycline-based antibiotics and medicines used for mononucleosis should not be taken at the same time as Ampiclox — always share your full medication list with your doctor.

Is this medicine safe for long-term use?
This medicine should only be used for the duration specifically prescribed by your doctor, to avoid unnecessary side effects and reduce the risk of contributing to antibiotic resistance.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.