Description

Description

Co-Trupril 20mg/12.5mg is an oral tablet that combines two active ingredients, Lisinopril and Hydrochlorothiazide, working together through complementary mechanisms to manage hypertension. Lisinopril, an ACE inhibitor, relaxes and widens blood vessels to make blood flow more easily, while Hydrochlorothiazide, a thiazide diuretic, increases urination to help remove excess fluid and sodium from the body. This combination is generally prescribed for patients whose blood pressure is not adequately controlled with a single medicine alone, particularly since Lisinopril also tends to counteract the potassium loss that diuretics like Hydrochlorothiazide can cause. The pack contains 28 tablets, suitable for continued daily use as part of a doctor-guided treatment plan.

Ingredients

Each Co-Trupril tablet contains 20mg of Lisinopril (as Dihydrate) combined with 12.5mg of Hydrochlorothiazide as its two active ingredients. The tablet also includes standard pharmaceutical excipients such as microcrystalline cellulose, anhydrous dibasic calcium phosphate, dried corn starch, aerosil, and magnesium stearate. Patients with known sensitivities to either active ingredient or any of the inactive components should check the packaging or consult a pharmacist before starting treatment.

Dosage Form

Co-Trupril is supplied as a solid oral tablet, meant to be swallowed whole with a glass of water, with or without food.

Uses

Co-Trupril is used for the treatment of mild to moderate hypertension in patients who are not adequately controlled with monotherapy alone. By combining Lisinopril’s blood-vessel-relaxing effect with Hydrochlorothiazide’s fluid-reducing action, this combination helps lower blood pressure more effectively while also helping to prevent complications such as heart attacks, strokes, and kidney problems associated with prolonged high blood pressure.

How to Use

Co-Trupril should be taken exactly as prescribed by a doctor, typically one tablet once daily, at approximately the same time each day. If the treatment effect is not satisfactory within two to four weeks at this dose, the doctor may consider increasing it, but this should only be done under medical supervision. For patients previously on diuretic therapy, the diuretic is typically stopped two to three days before starting Co-Trupril, as directed by the treating physician. The tablet can be taken with or without food, and this medicine should be continued consistently even if the patient feels well, since it manages blood pressure over the long term rather than providing immediate symptom relief. If a dose is missed, it should be taken as soon as remembered, unless it is close to the time of the next scheduled dose.

Side Effects

Common side effects of Co-Trupril include dizziness, headache, and mild digestive disturbances such as nausea or diarrhea. Some patients may also experience increased uric acid levels, which in certain individuals can lead to gout. Less commonly, more serious effects can occur, including angioedema (swelling of the face, lips, tongue, or throat), significant electrolyte imbalances, or a marked drop in blood pressure. Any of these serious symptoms should be reported to a doctor immediately.

Pregnancy & Breastfeeding

Co-Trupril must not be used during pregnancy, as ACE inhibitors like Lisinopril have been associated with a risk of harm to the developing baby, particularly during the second and third trimesters. Its use during breastfeeding is also generally discouraged, as both active ingredients may pass into breast milk. Women who are pregnant, planning to conceive, or breastfeeding should consult their doctor immediately for alternative treatment options.

Storage Instructions

Co-Trupril tablets should be stored in tightly closed packaging, in a dry place, protected from light, at a temperature below 30°C. The tablets should remain in their original packaging until needed and be kept well out of the reach of children. Any expired or unused tablets should be disposed of properly rather than through household waste.

FAQs

Why does Co-Trupril combine two active ingredients?
Combining Lisinopril and Hydrochlorothiazide provides more effective blood pressure control for patients not adequately managed by a single medicine, while Lisinopril also helps offset the potassium loss caused by the diuretic.

Can Co-Trupril’s dose be increased if blood pressure isn’t controlled?
Yes, if the effect isn’t satisfactory within two to four weeks, a doctor may consider increasing the dose, but this should only be done under medical supervision.

Can Co-Trupril be used by patients with kidney impairment?
It may be used in patients with creatinine clearance between 30 and 80 mL/min, but only after the doctor evaluates drug levels and kidney function.

Can Co-Trupril raise uric acid levels?
Yes, the thiazide component may increase uric acid levels in some patients, potentially triggering gout in susceptible individuals.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.