Description

Description

Duragesic 35/450mg is a pain-relief and muscle relaxant tablet manufactured by Tabros Pharma, a well-known pharmaceutical company in Pakistan. It combines Orphenadrine Citrate and Paracetamol in a single tablet, bringing together a central muscle relaxant with a widely used analgesic and fever-reducing agent. This medicine is commonly used to relieve muscle pain, spasms, and stiffness associated with conditions such as arthritis, sprains, strains, and tension headaches, while also helping to reduce accompanying pain and fever. By combining these two complementary actions, Duragesic offers relief from both the muscular tightness and the discomfort that often accompany musculoskeletal conditions. The pack contains 100 tablets, intended for use as directed by a physician.

Ingredients

Each tablet of Duragesic 35/450mg contains two active pharmaceutical ingredients working together. The first is Orphenadrine Citrate 35mg, a central muscle relaxant that works by acting on the central nervous system to help relieve muscle stiffness and spasms, in part through its anticholinergic properties, which help counteract certain nerve signals that contribute to muscle tightness. The second is Paracetamol 450mg, a well-established analgesic and antipyretic that helps reduce pain and lower fever by acting on pain and temperature-regulating pathways within the central nervous system. Together, these two ingredients address both the muscular component and the pain and fever associated with many musculoskeletal conditions, offering more complete symptom relief than either ingredient alone.

Dosage Form

Duragesic 35/450mg is supplied as an oral tablet. The tablets are packaged in blister strips, typically as multiple strips of 10 tablets each, with the full pack containing 100 tablets in total. This formulation is intended for oral use, generally taken two to three times daily, with the exact schedule determined by a physician based on the severity of symptoms.

Uses

Duragesic 35/450mg is primarily used for the relief of muscle pain, spasms, and inflammation associated with conditions such as rheumatoid arthritis, ankylosing spondylitis, muscle sprains, and knee pain. It is also commonly used to relieve tension headaches and general musculoskeletal discomfort where both muscle stiffness and pain are present. By combining a muscle relaxant with an analgesic, this medicine helps improve mobility and reduce discomfort for patients managing mild to moderate pain related to muscle tightness or spasm. It may also be used more broadly for short-term relief of pain and fever in situations where a doctor determines this combination to be an appropriate option.

How To Use

Duragesic 35/450mg should be taken exactly as directed by a physician, generally as one tablet taken two to three times a day, with or without food, though taking it with food may help reduce the likelihood of stomach upset. The tablet should be swallowed whole with a glass of water and should not be chewed, crushed, or broken. Taking the medicine at consistent times each day can help maintain steady levels in the body and support more reliable symptom relief. The recommended dosage should not be exceeded, particularly given the paracetamol component, since taking more than the advised amount can increase the risk of liver-related side effects. If a dose is missed, it should be taken as soon as it is remembered, unless it is close to the time of the next scheduled dose, in which case it should simply be skipped rather than doubled.

Side Effects

Duragesic 35/450mg may cause side effects in some patients, related to either of its two active ingredients. Commonly reported effects associated with the Orphenadrine component include dry mouth, nausea, blurred vision, dizziness, tremor, restlessness, and general stomach upset. Confusion has also been reported, particularly in elderly patients. Effects related to the Paracetamol component are generally rare at recommended doses but can include blood-related disorders in uncommon cases. Because this medicine contains paracetamol, taking more than the recommended dose can lead to serious liver toxicity, so the maximum daily dose should never be exceeded. Any signs of an overdose, including drowsiness, confusion, nausea, vomiting, loss of appetite, or yellowing of the skin or eyes, should be treated as a medical emergency requiring immediate attention. Any other unusual, severe, or persistent symptoms should always be discussed with a healthcare provider.

Pregnancy & Breastfeeding

The use of Duragesic 35/450mg during pregnancy should only be considered after consulting a doctor, who can weigh the potential benefits of symptom relief against any possible risks to the developing baby. Women who are pregnant, believe they may be pregnant, or are planning to conceive should discuss this with their doctor before starting or continuing treatment. Similarly, this medicine should only be used during breastfeeding if a doctor has confirmed it to be appropriate, taking into account the mother’s individual situation and the wellbeing of the nursing infant.

Storage Instructions

Duragesic 35/450mg tablets should be stored in a dry place, at or below 25°C, and protected from direct sunlight. The tablets should be kept in their original blister packaging until they are ready to be used, and the medicine should always be stored well out of the reach and sight of children. Tablets should not be used once the expiry date printed on the packaging has passed.

FAQS

Q: Is Duragesic 35/450mg an antibiotic?
No, this medicine is not an antibiotic; it is a pain-relieving muscle relaxant combination used to manage muscle pain, spasms, and associated discomfort.

Q: Can this medicine cause drowsiness?
Yes, some people may feel drowsy, dizzy, or light-headed after taking this medicine, so caution should be used when driving or performing tasks that require alertness until the individual’s response to the medicine is known.

Q: Why is it important not to exceed the recommended dose?
Because this medicine contains paracetamol, taking more than the recommended amount can increase the risk of serious liver damage, so the maximum daily dose advised by a doctor should never be exceeded.

Q: What should be done if a dose is missed?
The missed dose should be taken as soon as it is remembered, unless it is close to the time of the next scheduled dose, in which case it should simply be skipped rather than doubled.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.