Description

Description

Entamizole DS (500/400mg) is a double-strength combination oral medication manufactured by Abbott Laboratories, formulated to help treat intestinal amoebiasis and related parasitic infections in cases requiring a more concentrated dose. Each pack contains 15 tablets, and every tablet brings together two active substances, Diloxanide Furoate and Metronidazole, that work through complementary mechanisms to address different stages of amoebic infection. Diloxanide Furoate primarily acts against the amoebic cysts residing within the intestinal lumen, while Metronidazole works against the actively invasive form of the parasite, making the combination useful for addressing both the visible infection and the underlying cause more comprehensively. As a double-strength formulation, Entamizole DS allows for a higher dose per tablet, which may support a more convenient dosing schedule in cases where a stronger or more concentrated treatment approach is clinically appropriate. Entamizole DS should only be used under medical supervision, with the exact treatment plan, including dosage and duration, determined by a qualified physician based on the confirmed diagnosis and severity of infection.

Ingredients

Each tablet of Entamizole DS (500/400mg) contains Diloxanide Furoate 500mg, an amoebicide that acts primarily within the intestinal lumen to eliminate amoebic cysts, together with Metronidazole 400mg, an antiprotozoal and antibacterial agent that works by disrupting the DNA of susceptible organisms, including the invasive form of the amoeba responsible for tissue infection. This double-strength formulation delivers twice the active ingredient content found in the standard Entamizole formulation, distinguishing it as a more concentrated option for cases requiring stronger treatment coverage. The tablet also contains standard pharmaceutical excipients such as binders, fillers, and coating agents that support tablet stability, appearance, and shelf life without contributing any therapeutic effect of their own.

Dosage Form

Entamizole DS is available as an oral tablet, with each pack containing 15 tablets. This tablet form allows for convenient, consistent dosing of both active ingredients together at a higher concentration, as directed by a treating physician.

Uses

Entamizole DS (500/400mg) is primarily used for the treatment of intestinal amoebiasis, a parasitic infection of the digestive tract that can cause symptoms such as diarrhea, abdominal cramps, and in some cases, more significant gastrointestinal disturbance. This double-strength formulation is generally considered for cases where a more concentrated treatment approach is clinically appropriate, allowing for effective dosing with fewer tablets compared to the standard strength. By combining an agent effective against amoebic cysts with one effective against the actively invasive form of the parasite, this medicine is intended to provide thorough treatment coverage, and it may also be used for certain other protozoal or anaerobic bacterial infections as determined by a treating physician based on diagnostic findings.

How to Use

Entamizole DS should be taken exactly as prescribed by a doctor, typically for a defined course of treatment rather than an open-ended duration, and is generally taken with food to help reduce the likelihood of stomach discomfort, particularly given its higher concentration. The tablet should be swallowed whole with a glass of water and should not be crushed or chewed unless specifically advised by a healthcare provider. It is important to complete the full prescribed course of treatment, even if symptoms improve before the course is finished, as stopping early may allow the infection to persist or recur. Alcohol should be strictly avoided during treatment and for a period afterward, as combining alcohol with Metronidazole can cause an unpleasant reaction involving symptoms such as flushing, nausea, and a rapid heartbeat. If a dose is missed, it should be taken as soon as remembered, unless it is close to the time of the next scheduled dose, in which case the missed dose should be skipped rather than doubled.

Side Effects

Entamizole DS may cause side effects in some individuals, and because this is a double-strength formulation, certain effects may be more pronounced compared to the standard strength. Commonly reported effects include nausea, metallic taste in the mouth, loss of appetite, and mild gastrointestinal discomfort such as stomach upset or diarrhea. Less commonly, some individuals may experience dizziness, headache, or dark-colored urine, which is generally harmless but can be discussed with a doctor if concerning. Because Metronidazole can interact significantly with alcohol, avoiding alcoholic beverages throughout treatment is important to prevent adverse reactions, and this precaution is particularly relevant given the higher Metronidazole content in this formulation. Any severe or persistent symptoms, signs of nerve-related effects such as numbness or tingling with prolonged use, or signs of an allergic reaction such as rash or facial swelling require prompt medical attention. This list is not exhaustive, and a healthcare provider should be consulted for a complete understanding of possible reactions at this strength.

Pregnancy & Breastfeeding

Entamizole DS is generally not recommended during the first trimester of pregnancy, and its use during later stages of pregnancy should only occur if a doctor determines that the benefit clearly outweighs the potential risk, as both active ingredients require careful individual evaluation during pregnancy, particularly at this higher strength. Women who are pregnant, planning a pregnancy, or suspect they may be pregnant should inform their doctor immediately so that a suitable treatment approach can be discussed. Use during breastfeeding is also generally not recommended without medical guidance, as Metronidazole is known to pass into breast milk, and a doctor may advise a temporary pause in breastfeeding during treatment. Any decision regarding use during pregnancy or lactation should be made only through careful consultation with a qualified healthcare professional.

Storage Instructions

Entamizole DS tablets should be stored in a cool, dry place away from direct sunlight, excessive heat, and moisture, ideally below 30°C. The tablets should remain in their original packaging until ready for use, and the product should always be kept out of the reach and sight of children. Tablets should not be used beyond their printed expiry date, and any unused or expired medicine should be disposed of responsibly according to local pharmaceutical waste guidelines rather than discarded in regular household trash.

FAQS

How is Entamizole DS different from the standard Entamizole formulation?
Entamizole DS is a double-strength formulation containing twice the active ingredient content, allowing for effective treatment with fewer tablets in cases requiring a more concentrated approach.

Can alcohol be consumed while taking Entamizole DS?
No, alcohol should be strictly avoided during treatment and for a period afterward, as it can react with the Metronidazole component and cause unpleasant symptoms such as flushing and nausea.

Is it necessary to complete the full course of Entamizole DS?
Yes, the full prescribed course should be completed even if symptoms improve early, as stopping treatment prematurely may allow the infection to persist or return.

Why might a doctor prescribe the DS formulation instead of the standard strength?
The double-strength formulation may be prescribed when a more concentrated treatment approach is clinically appropriate, allowing for a more convenient dosing schedule with fewer tablets.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.