Description

Description

Inosita Plus XR is a prescription-only combination medicine manufactured by PharmaEvo, formulated to help adults manage type 2 diabetes mellitus. Each pack contains 14 extended-release tablets, with each tablet combining two well-established anti-diabetic molecules — Sitagliptin 100mg and Metformin 1000mg — in a single dosage form. This is the highest-strength combination in the Inosita Plus XR range, typically prescribed for patients who require the maximum recommended Sitagliptin dose alongside a higher Metformin dose, when lower-strength combinations or lifestyle measures alone have not achieved adequate blood sugar control. The extended-release (XR) formulation is designed to release the medicine gradually into the bloodstream, which may help maintain steadier glucose control throughout the day and reduce the frequency of dosing compared to immediate-release tablets. Inosita Plus XR should only be used under the supervision of a qualified physician, as part of a broader diabetes management plan that includes monitoring, diet, and lifestyle adjustments.

Ingredients

Each extended-release tablet of Inosita Plus XR (100/1000mg) contains Sitagliptin 100mg (as Sitagliptin Phosphate Monohydrate), a DPP-4 inhibitor that helps increase insulin release and reduce sugar production by the liver, along with Metformin Hydrochloride 1000mg, a biguanide that improves the body’s sensitivity to insulin and reduces glucose absorption from the intestines. The tablet also contains standard pharmaceutical excipients required for tablet formation and the extended-release mechanism, added in regulator-approved quantities.

Dosage Form

Inosita Plus XR is available as an oral extended-release (XR) film-coated tablet. The extended-release design allows the active ingredients to be absorbed more gradually compared to standard tablets, supporting more consistent blood sugar control across the day. This strength, 100/1000mg, represents the maximum daily Sitagliptin dose combined with a higher Metformin dose, and is generally reserved for patients whose treatment plan calls for full-strength combination therapy.

Uses

Inosita Plus XR (100/1000mg) is primarily used for managing blood glucose levels in adults diagnosed with type 2 diabetes mellitus who require the maximum recommended Sitagliptin dose along with a higher Metformin dose. It is often prescribed as a step-up therapy alongside diet and exercise when lower-strength combinations have not provided adequate control, and it can also support patients who have specifically been prescribed this Sitagliptin–Metformin strength by their doctor as their ongoing maintenance treatment. This medicine is not intended for type 1 diabetes or for the treatment of diabetic ketoacidosis.

How to Use

Inosita Plus XR should only be taken exactly as directed by your physician. Tablets are usually taken with meals to reduce stomach discomfort and support absorption, and should be swallowed whole with a glass of water — extended-release tablets should never be crushed, split, or chewed, as this can affect how the medicine is released. It’s best to take the medicine at the same time each day to maintain steady blood levels, and the dose should never be stopped, increased, or changed without consulting your doctor, even if blood sugar levels appear to have improved. Since this is the highest-strength formulation in the range, your doctor will typically have arrived at this dose gradually, after assessing how you responded to lower strengths, so it should not be started as an initial dose without medical guidance. If a dose is missed, it should be taken as soon as remembered unless it is close to the time of the next dose, in which case the missed dose should simply be skipped rather than doubled up.

Side Effects

As with any medicine, Inosita Plus XR may cause side effects in some individuals, and at this higher combined strength, gastrointestinal effects may be more noticeable, particularly when starting treatment or shortly after a dose increase. Commonly reported effects include nausea, diarrhea, stomach upset, reduced appetite, or a metallic taste. Less commonly, some people may experience headache, dizziness, or low blood sugar, especially if combined with other diabetes medicines. Rare but serious effects can include lactic acidosis, a Metformin-related risk that is more likely in people with kidney or liver problems, along with pancreatitis or allergic reactions such as rash, swelling, or difficulty breathing. If you notice unusual muscle pain, severe stomach pain, difficulty breathing, or signs of an allergic reaction, seek medical attention immediately. This list is not exhaustive, and any unexpected symptoms should always be reported to your doctor or pharmacist.

Pregnancy & Breastfeeding

Inosita Plus XR is generally not recommended during pregnancy, as insulin is usually the preferred treatment for blood sugar control in pregnant women with diabetes. It is also not typically recommended while breastfeeding, since it is not fully established how much of the medicine passes into breast milk. Women who are pregnant, planning a pregnancy, or breastfeeding should consult their doctor before starting or continuing this medicine, so that a safer alternative can be considered if needed.

Storage Instructions

Store Inosita Plus XR tablets at room temperature, away from direct sunlight, heat, and moisture. Keep the medicine in its original packaging until ready to use, and keep it out of reach of children and pets. Do not use the medicine beyond its printed expiry date, and dispose of any expired or unused tablets according to local pharmaceutical waste guidelines rather than household trash.

FAQs

Can I take Inosita Plus XR (100/1000mg) without a prescription?
No, this is a prescription medicine and should only be used under a doctor’s guidance, particularly since it is the highest-strength formulation available.

How is this different from the 50/1000mg version?
Both contain the same Metformin dose, but this version contains double the Sitagliptin dose, and is prescribed based on how well a patient responds to lower strengths.

Can I start treatment directly on this strength?
Typically no — doctors usually begin with a lower strength and adjust the dose gradually based on response and tolerability.

What should I do if I miss a dose?
Take it as soon as you remember, unless it’s near your next scheduled dose, in which case you should skip the missed one.

Is it safe for long-term use?
Many patients use Metformin-Sitagliptin combinations long-term under regular medical supervision, including periodic kidney and liver function checks.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.