Description

Description

Linjardy MXR 25/5/1000mg is the highest-strength option in the Linjardy MXR range, combining the maximum available Empagliflozin dose with the full Linagliptin dose and extended-release Metformin in a single once-daily tablet, packaged 14 tablets to a pack. It brings together Empagliflozin, an SGLT2 inhibitor that helps the kidneys clear excess glucose through urine, Linagliptin, a DPP-4 inhibitor that supports insulin release around mealtimes while reducing the liver’s glucose output, and an extended-release form of Metformin, which steadily improves the body’s sensitivity to its own insulin throughout the day. This top strength is generally reserved for patients who are already well established on the individual components and require the fullest available combined effect from a single daily tablet.

Ingredients

Each Linjardy MXR 25/5/1000mg tablet contains:

• Empagliflozin – 25 mg (immediate-release layer)
• Linagliptin – 5 mg
• Metformin Hydrochloride – 1000 mg (extended-release core)

The tablet also contains standard inactive excipients that form the extended-release matrix and outer film coating, which regulate the gradual release of Metformin and support easy swallowing, without any therapeutic effect of their own.

Dosage Form

Linjardy MXR 25/5/1000mg is manufactured as an extended-release, film-coated oral tablet, supplied 14 tablets per pack, intended for once-daily oral use.

Uses

Linjardy MXR 25/5/1000mg is generally prescribed to:

• Improve blood glucose control in adults with type 2 diabetes mellitus who require the maximum available Empagliflozin dose combined with the full Linagliptin dose and extended-release Metformin
• Allow patients already stabilized on Empagliflozin 25mg, Linagliptin 5mg, and Metformin taken as separate medicines to move to a more convenient once-daily extended-release tablet
• Support long-term diabetes management goals, including potential cardiovascular and kidney-related benefits, when paired with an appropriate diet and consistent physical activity

It is not intended for people with type 1 diabetes or for the management of diabetic ketoacidosis.

How to Use

The points below are general guidance only — always follow the exact instructions given by your prescribing doctor:

• Take the tablet once daily, generally with the evening meal, as directed by your doctor.
• Swallow the tablet whole with a glass of water; because it is extended-release, never crush, split, or chew it, as this can cause the metformin dose to release too quickly.
• It’s normal to occasionally notice the outer tablet shell in the stool, since this part of the extended-release matrix is not fully absorbed; this does not mean the medicine was ineffective.
• Maintain a consistent daily timing to support stable blood sugar management.
• Attend recommended blood tests, including kidney function and blood pressure monitoring, since safe use at this maximum strength depends closely on adequate kidney health.

Side Effects

Side effects can vary between individuals, but commonly reported ones with this combination include:

• Nausea, diarrhea, or general stomach discomfort, typically milder than with immediate-release metformin, especially once the body adjusts
• Increased urinary frequency, often more pronounced at this maximum Empagliflozin dose
• Mild dehydration or increased thirst
• Urinary tract or genital yeast infections
• Upper respiratory symptoms such as a runny or stuffy nose

Less commonly, more serious concerns can occur, including a marked drop in blood pressure, lactic acidosis (a rare but serious risk associated with metformin, more likely with reduced kidney or liver function), signs of pancreatitis such as persistent abdominal pain, joint pain associated with DPP-4 inhibitors, or symptoms suggesting diabetic ketoacidosis such as ongoing nausea, vomiting, or abdominal pain even when blood sugar readings appear normal. Any of these symptoms require urgent medical attention. This overview is not exhaustive, so any unusual or persistent symptom should be discussed with a doctor or pharmacist.

Pregnancy & Breastfeeding

Linjardy MXR 25/5/1000mg is generally not recommended during pregnancy, since the Empagliflozin component may affect fetal kidney development, particularly in later stages of pregnancy, and diabetes management in pregnant women is typically handled through alternative approved treatments under specialist care. It is also generally not advised while breastfeeding. Women who are pregnant, planning to become pregnant, or currently breastfeeding should speak with their doctor before starting or continuing this medication.

Storage Instructions

• Store Linjardy MXR 25/5/1000mg tablets at room temperature, ideally below 25°C, away from direct sunlight, heat, and excess humidity.
• Keep tablets in their original blister packaging until they are needed.
• Store out of reach of children.
• Do not use tablets past their printed expiry date, and dispose of unused medicine responsibly rather than through household waste.

FAQS

Is 25/5/1000mg the strongest Linjardy MXR option available?
Yes, this strength contains the maximum Empagliflozin dose combined with the full Linagliptin dose and the maximum extended-release Metformin content in this product line.

Why is closer monitoring recommended at this dose?
Because it combines the highest Empagliflozin strength with full-dose Linagliptin and maximum Metformin, your doctor will likely monitor kidney function, hydration, and blood pressure more closely to reduce the risk of complications.

Can I move directly to 25/5/1000mg from a lower MXR strength?
No, dose increases should always happen gradually and only under a doctor’s supervision, based on how well you tolerate each step.

Why can’t I split or crush this tablet?
Breaking the tablet disrupts the extended-release mechanism, causing the full metformin dose to release all at once rather than gradually, which raises the risk of side effects.

Is this strength suitable if I have reduced kidney function?
This maximum strength generally requires normal or near-normal kidney function, so your doctor will assess your kidney health carefully before prescribing it.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.