Description

Description

Magnesium Sulphate (50%w/v) Injection 10ml is a concentrated electrolyte replenisher containing Magnesium Sulphate Heptahydrate as its active ingredient. This 50% w/v formulation is a highly concentrated solution used to correct magnesium deficiency and to manage certain pregnancy-related conditions involving seizure risk. Magnesium is essential for numerous bodily functions, including nerve signaling, muscle relaxation, and enzymatic processes, and low levels can lead to a range of symptoms affecting the heart, muscles, and nervous system. The larger 10ml vial size makes this formulation particularly suitable for situations requiring higher total doses, such as continuous infusions or protocols involving repeated administration, and it is used exclusively in hospital and clinical settings under close medical supervision.

Ingredients

Each milliliter of the 50%w/v solution contains 500mg of Magnesium Sulphate Heptahydrate, meaning a 10ml vial provides approximately 5g of Magnesium Sulphate Heptahydrate (equivalent to around 20 mmol of magnesium ions), along with water for injection and pH-adjusting agents such as sulfuric acid and/or sodium hydroxide.

Dosage Form

Magnesium Sulphate 50%w/v is supplied as a clear, sterile, concentrated solution for injection in a 10ml single-use vial or ampoule, suitable for intramuscular injection or, after appropriate dilution, for intravenous administration or infusion.

Uses

This injection is primarily used to treat confirmed magnesium deficiency (hypomagnesemia), particularly in cases linked to malabsorption disorders, chronic alcohol use, or extended parenteral nutrition. It also plays a vital role in preventing and controlling seizures associated with eclampsia and severe pre-eclampsia during pregnancy. Additionally, because of the larger volume per vial, this strength is often used when higher cumulative doses are needed, such as for continuous intravenous infusions in more severe or ongoing deficiency states.

How to Use

Magnesium Sulphate 50%w/v is administered only by a doctor or trained healthcare professional, either through deep intramuscular injection or intravenous administration after careful dilution — the concentrated solution must never be given intravenously in its undiluted form. For intravenous infusions, the total dose is typically diluted in a compatible solution and administered slowly over a set period to avoid a rapid rise in blood magnesium levels. Dosing depends on the severity of the condition, the patient’s weight, and ongoing monitoring of blood magnesium levels, blood pressure, and reflexes, particularly when used for eclampsia management. This medicine should never be self-administered.

Side Effects

Because of its concentrated strength, Magnesium Sulphate 50%w/v carries a risk of side effects if administered too quickly or in excessive amounts. Reported effects include flushing, sweating, and a marked drop in blood pressure. Higher magnesium levels can lead to more serious effects such as lowered body temperature, drowsiness, reduced reflexes, muscle weakness, and, in severe cases, slowed breathing or respiratory depression, which is why careful monitoring throughout treatment is essential. Pain or discomfort at the injection site may also occur with intramuscular use. Regular blood magnesium level checks are typically part of the treatment protocol to prevent excessive accumulation.

Pregnancy & Breastfeeding

Magnesium Sulphate 50%w/v is specifically used during pregnancy under close medical supervision, particularly for the prevention and management of seizures related to eclampsia and severe pre-eclampsia. Treatment is carefully monitored by an obstetrician, with regular checks of blood pressure, reflexes, and magnesium levels. For breastfeeding mothers, its use should be guided by a doctor, who will assess the clinical necessity against any potential considerations for the nursing infant.

Storage Instructions

Store Magnesium Sulphate 50%w/v vials at controlled room temperature, generally between 15–30°C, and avoid freezing. Keep the vial in its original packaging until ready for use, and store it out of the reach of children. This product is intended for single-dose use, and any unused portion should be discarded rather than stored for later use. Do not use the injection if the solution appears discolored, cloudy, or contains visible particles.

FAQs

Why is the 50%w/v strength commonly used for infusions?
Its concentrated nature and larger 10ml volume make it convenient for preparing diluted infusions that require a higher total magnesium dose.

Can the 50% solution be injected intravenously without dilution?
No, it must always be diluted to a lower concentration before intravenous administration to avoid complications.

What monitoring is required during treatment?
Blood magnesium levels, blood pressure, and reflexes are typically monitored throughout treatment, especially when used for eclampsia management.

Is this injection safe for use in children?
It can be used in children, but the concentration must be diluted appropriately and administration closely supervised by a doctor.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.