Description

Description

Moduretic (5/50mg) is a combination diuretic medicine manufactured by OBS Pakistan, formulated with Amiloride Hydrochloride and Hydrochlorothiazide as its active ingredients. It brings together a potassium-sparing diuretic and a thiazide diuretic in a single tablet, offering effective fluid and blood pressure control while helping protect against potassium loss. This pack contains 100 tablets, each combining 5mg of amiloride with 50mg of hydrochlorothiazide. Moduretic is commonly used for managing high blood pressure, fluid retention, and heart failure, working by increasing urine output to remove excess salt and water while maintaining healthier potassium balance in the body.

Ingredients

Each Moduretic tablet contains Amiloride Hydrochloride 5mg and Hydrochlorothiazide 50mg. Hydrochlorothiazide works by increasing the flow of urine, helping the body eliminate excess water and salt, which in turn helps lower blood pressure. Amiloride, a potassium-sparing diuretic, acts on the kidneys to block sodium reabsorption while preventing excessive potassium loss, a common side effect of thiazide diuretics used alone. Together, these two compounds provide effective diuretic and antihypertensive action while helping maintain a healthier electrolyte balance. The tablet also contains standard inactive excipients used for formulation and stability.

Dosage Form

Moduretic is available as an oral tablet, supplied in a pack of 100 tablets. This larger pack size supports ongoing daily therapy for patients managing chronic conditions requiring ongoing diuretic treatment.

Uses

Moduretic is primarily used to treat high blood pressure, either alone or combined with other antihypertensive medicines. It is also used to manage fluid retention and swelling associated with congestive heart failure, liver cirrhosis, and chronic kidney conditions. By combining a diuretic effect with potassium protection, Moduretic is particularly useful for patients who need to avoid low potassium levels, such as those with certain heart rhythm concerns or those on other medications affecting potassium balance.

How to Use

Moduretic tablets should be taken exactly as prescribed by a physician, generally once daily, with or without food. It is best to take the medicine in the morning to avoid increased nighttime urination, and the last dose of the day should generally be taken no later than early evening unless otherwise directed. The tablet should be swallowed whole with a glass of water, and the dosage should not be adjusted without medical guidance, as this medicine combines two active compounds with distinct effects on the body.

Side Effects

Common side effects of Moduretic may include increased urination, dizziness, headache, and fatigue or weakness due to fluid and electrolyte shifts. Some patients may also experience nausea or mild gastrointestinal discomfort. Because the medicine affects both sodium and potassium levels, periodic monitoring of electrolytes and kidney function is often recommended, particularly for patients with diabetes or existing kidney concerns. Any signs of dehydration, muscle weakness, or irregular heartbeat should be reported to a doctor promptly.

Pregnancy & Breastfeeding

Moduretic should only be used during pregnancy if a physician determines that the potential benefit outweighs any possible risk, as combination diuretics require careful evaluation during this period. Breastfeeding mothers should also consult their doctor before using this medicine, as its components may pass into breast milk and require medical guidance regarding continued use.

Storage Instructions

Store Moduretic tablets at room temperature, away from direct heat, sunlight, and moisture. Keep the tablets in their original packaging until ready for use to protect them from environmental exposure. Store the medicine out of reach of children and pets, and do not use tablets beyond their printed expiry date.

FAQS

Why is Moduretic preferred over a single diuretic for some patients?
It combines a diuretic effect with potassium protection, reducing the risk of low potassium levels that can occur with thiazide diuretics alone.

What is the best time of day to take Moduretic?
It is generally best taken in the morning to avoid frequent urination disrupting sleep at night.

Can Moduretic be used by diabetic patients?
It should be used with caution in diabetic patients, and blood sugar and kidney function should be monitored regularly.

Does Moduretic require regular blood testing?
Yes, periodic monitoring of electrolytes and kidney function is often recommended during treatment.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.