Description

Description

Empoli Plus 12.5/500mg is a combination tablet manufactured by Sami Pharmaceuticals, containing Empagliflozin and Metformin together, with a higher strength of Empagliflozin paired with a lower strength of Metformin compared to some other combinations in this range. This formulation brings together two distinct classes of diabetes medication to provide more comprehensive blood sugar control. Empagliflozin, at this higher strength, works by reducing glucose reabsorption in the kidneys, allowing a greater amount of excess sugar to be removed from the body through urine, while Metformin reduces the amount of glucose produced by the liver and improves the body’s sensitivity to insulin. This particular combination may be considered for patients who benefit from a stronger SGLT2 inhibitor effect while using a more moderate Metformin dose, based on their individual tolerance and treatment needs. Each pack of Empoli Plus 12.5/500mg contains 14 tablets, generally intended for twice-daily use as part of a treatment plan established by a physician.

Ingredients

Each Empoli Plus 12.5/500mg tablet contains two active pharmaceutical ingredients: Empagliflozin at a strength of 12.5mg and Metformin at a strength of 500mg. The tablet also includes standard pharmaceutical excipients, such as fillers, binding agents, and a film-coating layer, which support the tablet’s stability and ease of swallowing without contributing to its therapeutic effect.

Dosage Form

Empoli Plus 12.5/500mg is formulated as a film-coated oral tablet, combining 12.5mg of Empagliflozin with 500mg of Metformin in each unit. The tablets are supplied with a total of 14 units per pack, intended for oral administration only.

Uses

Empoli Plus 12.5/500mg is primarily used to help manage blood sugar levels in adults with type 2 diabetes who benefit from a higher dose of Empagliflozin combined with a moderate dose of Metformin. This particular strength combination may be selected by a doctor based on a patient’s individual response to each component, tolerance to Metformin-related digestive effects, and overall blood sugar control needs. By combining these two mechanisms, this medicine offers a broader approach to blood sugar reduction, helping to lower the long-term risks associated with poorly controlled diabetes, including damage to the eyes, kidneys, nerves, and blood vessels. It may be used as part of a wider treatment plan that also includes dietary and lifestyle adjustments recommended by a healthcare provider.

How to Use

Empoli Plus 12.5/500mg should be taken exactly as directed by a prescribing physician, typically twice daily with meals, as taking Metformin with food helps reduce the likelihood of stomach upset. The tablet should be swallowed whole with a glass of water and should not be crushed, split, or chewed unless a doctor has specifically advised otherwise. Because this medication includes a higher dose of Empagliflozin, maintaining good hydration is especially important, particularly during illness or hot weather. Doses should not be skipped, and treatment should not be stopped suddenly without consulting a doctor. If a dose is missed, it should be taken as soon as remembered, unless the next dose is nearly due, in which case the missed dose should be skipped rather than doubled.

Side Effects

Because this tablet contains a higher dose of Empagliflozin, certain effects related to this component may be somewhat more noticeable, though individual responses vary. Commonly reported effects include increased urination, urinary tract infections, and genital yeast infections, related to the higher Empagliflozin dose, alongside gastrointestinal symptoms such as nausea, diarrhea, and stomach discomfort linked to the Metformin component. Some patients may also experience a metallic taste, reduced appetite, or mild dehydration, particularly if fluid intake is not well maintained. Less commonly, effects such as dizziness may occur. In rare but serious cases, this medication has been associated with a condition called lactic acidosis, related to the Metformin component, as well as diabetic ketoacidosis, related to the Empagliflozin component; both are medical emergencies requiring immediate attention, with symptoms such as unusual muscle pain, difficulty breathing, severe stomach pain, or unusual tiredness warranting urgent medical evaluation. Patients on this higher Empagliflozin dose should be particularly attentive to signs of urinary or genital infections and dehydration.

Pregnancy & Breastfeeding

Empoli Plus 12.5/500mg is generally not recommended during pregnancy, as the safety of Empagliflozin for the developing baby has not been well established, and alternative treatments, including insulin, are typically preferred during this period. Women who are pregnant, planning to become pregnant, or breastfeeding should inform their doctor, as this medication is also not generally recommended during breastfeeding, and a suitable alternative treatment plan will usually be discussed.

Storage Instructions

Empoli Plus 12.5/500mg tablets should be stored in a cool, dry place, away from direct sunlight and excessive humidity. It is best to keep the tablets in their original packaging until they are needed and to store them securely out of the reach of children and pets. Tablets should not be used after the expiry date printed on the packaging.

FAQs

Why does this combination pair a higher Empagliflozin dose with a lower Metformin dose?
Doctors may select this specific combination based on a patient’s individual tolerance to Metformin’s digestive effects while still benefiting from a stronger Empagliflozin effect, tailoring the balance to the patient’s needs.

Is the risk of urinary or genital infection higher with this combination?
Since this tablet contains a higher dose of Empagliflozin, patients may be somewhat more prone to these infections, so maintaining good hygiene and hydration is especially important.

What is lactic acidosis, and why is it a concern with this medication?
Lactic acidosis is a rare but serious condition related to the Metformin component, where lactic acid builds up in the blood; symptoms such as unusual muscle pain, difficulty breathing, or severe tiredness should be reported to a doctor immediately.

Can this medication be paused before certain medical procedures?
Yes, your doctor may advise temporarily stopping this medication before procedures involving contrast dye or surgery, due to the Metformin component, so always inform your healthcare team that you are taking this medicine.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.