Description

Description

Jentin-Met 50mg/1000mg is an oral tablet that combines two active ingredients, Sitagliptin and Metformin Hydrochloride, working together through complementary mechanisms to help control blood sugar in adults with type 2 diabetes. Sitagliptin, a DPP-4 inhibitor, increases and prolongs the activity of natural hormones called incretins, boosting insulin release and reducing glucagon levels in a glucose-dependent manner, while Metformin, a biguanide, lowers both fasting and after-meal blood glucose by reducing liver glucose production and improving insulin sensitivity. This particular strength offers a higher Metformin dose within the combination, often used for patients who require more intensive glucose control from that component specifically. The pack contains 14 tablets, suitable for continued daily use as part of a broader diabetes management plan.

Ingredients

Each Jentin-Met 50mg/1000mg tablet contains Sitagliptin Phosphate Monohydrate equivalent to 50mg of Sitagliptin, combined with 1000mg of Metformin Hydrochloride as its two active ingredients. The tablet also includes standard pharmaceutical excipients such as binders, fillers, and a film coating, which help maintain the tablet’s structure and support consistent absorption once ingested. Patients with known sensitivities to either active ingredient or any of the inactive components should check the packaging or consult a pharmacist before starting treatment.

Dosage Form

Jentin-Met 50mg/1000mg is supplied as a solid, film-coated oral tablet, meant to be swallowed whole with a glass of water, without crushing, breaking, or chewing.

Uses

Jentin-Met 50mg/1000mg is indicated as an adjunct to diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus, particularly when a lower-strength combination or single-ingredient treatment has not achieved adequate glucose management. By combining Sitagliptin’s incretin-based effect with a higher dose of Metformin’s ability to reduce liver glucose production, this combination helps regulate both fasting and after-meal blood sugar levels for patients with greater glucose-lowering needs. It is not intended for use in patients with type 1 diabetes or for treating diabetic ketoacidosis.

How to Use

Jentin-Met 50mg/1000mg should be taken exactly as prescribed by a doctor, generally with meals to help reduce stomach-related side effects associated with the higher Metformin dose. The tablet should be swallowed whole with a glass of water and should not be crushed, broken, or chewed. The dosage should be adjusted based on self-monitoring of blood glucose levels and the individual’s clinical response, with the maximum recommended Sitagliptin dose generally not exceeding 100mg per day and Metformin not exceeding 2000mg per day. Alongside this medicine, patients are generally encouraged to maintain a healthy diet and regular exercise routine. If a dose is missed, it should be taken as soon as remembered, unless it is close to the time of the next scheduled dose.

Side Effects

Common side effects of Jentin-Met 50mg/1000mg include nausea, upper abdominal pain, and diarrhea, which may be more noticeable at this higher Metformin strength, particularly when treatment is first started. Some patients may also experience drowsiness or a decrease in blood glucose levels. Less commonly, more serious effects can occur, such as signs of lactic acidosis, a rare but serious condition associated with Metformin, or pancreatitis. Any unusual symptoms, including severe abdominal pain, muscle pain, breathing difficulty, or severe fatigue, should be reported to a doctor immediately.

Pregnancy & Breastfeeding

Jentin-Met 50mg/1000mg is generally not recommended during pregnancy, as the safety of the Sitagliptin component for a developing baby has not been fully established, even though Metformin is sometimes used during pregnancy under close medical supervision. Its use during breastfeeding is also generally discouraged due to limited safety data on the combined formulation. Women who are pregnant, planning to conceive, or breastfeeding should consult their doctor before starting this medicine.

Storage Instructions

Jentin-Met 50mg/1000mg tablets should be stored at room temperature, in a dry place away from direct sunlight and excess heat. The tablets should be kept in their original packaging until needed and stored well out of the reach of children and pets. Tablets should not be used past their expiry date, and any expired or unused tablets should be disposed of properly.

FAQs

Why might a doctor prescribe the 1000mg Metformin strength instead of 500mg?
The higher Metformin dose is generally used when a patient requires more intensive glucose-lowering support from that component specifically, based on their overall treatment response.

Why is Jentin-Met 50mg/1000mg often taken with meals?
Taking it with food helps reduce the stomach-related side effects, such as nausea or diarrhea, that are commonly associated with the Metformin component, especially at this higher strength.

Can Jentin-Met 50mg/1000mg be used by patients with type 1 diabetes?
No, it is intended specifically for type 2 diabetes and is contraindicated in patients with diabetic ketoacidosis.

What is the maximum recommended daily dose of Metformin within this combination?
The maximum recommended dose is generally 2000mg of Metformin per day, adjusted based on blood glucose monitoring and clinical response.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.