Description

Description

Progrel-AP 75/75mg is a dual antiplatelet tablet manufactured by Tabros Pharma, a well-known pharmaceutical company in Pakistan. This formulation brings together two antiplatelet medicines, Clopidogrel and Aspirin, in a single tablet, working through different mechanisms to reduce the ability of blood platelets to clump together and form clots. It is commonly used in patients with cardiovascular disease, particularly those who have experienced a heart attack, stroke, or acute coronary syndrome, as well as those who have undergone procedures such as angioplasty or stent placement. By combining these two antiplatelet agents, this medicine offers a more comprehensive approach to preventing dangerous blood clots that could otherwise block blood flow to the heart or brain. The pack contains 30 tablets, intended for continued once-daily use under the close supervision of a physician.

Ingredients

Each tablet of Progrel-AP 75/75mg contains two active pharmaceutical ingredients working together. The first is Clopidogrel 75mg, a medicine belonging to a class known as thienopyridines, which works by blocking a specific receptor on the surface of platelets, preventing them from being activated and from clumping together to form a clot. The second is Aspirin 75mg, a well-established antiplatelet agent that works by blocking an enzyme involved in producing a substance called thromboxane, which platelets rely on to trigger clotting and cause blood vessels to narrow. By reducing thromboxane production, Aspirin further limits the platelets’ ability to stick together. Together, these two ingredients target platelet aggregation through separate, complementary pathways, offering a stronger combined protective effect against clot formation than either medicine used alone.

Dosage Form

Progrel-AP 75/75mg is supplied as an oral tablet. The tablets are packaged in blister strips, typically as three strips of 10 tablets each, with the full pack containing 30 tablets in total. This combination is intended for once-daily oral administration, generally taken with the evening meal as part of a structured, physician-guided treatment plan.

Uses

Progrel-AP 75/75mg is primarily used for the prevention of blood clot formation in patients with cardiovascular disease, particularly following a heart attack, stroke, or diagnosis of acute coronary syndrome. It is also commonly prescribed after procedures such as angioplasty or the placement of a coronary stent, where maintaining smooth, uninterrupted blood flow through the treated vessel is essential to prevent re-blockage. This combination may additionally be used in patients with peripheral artery disease, where narrowed blood vessels in the limbs increase the risk of clot-related complications. By working together to reduce platelet clumping, this medicine helps lower the long-term risk of further heart attacks, strokes, and other serious cardiovascular events in patients who are considered to be at higher risk.

How To Use

Progrel-AP 75/75mg should only be taken exactly as prescribed by a registered physician, particularly given the intensity of dual antiplatelet therapy. The tablet is generally taken once daily, with the evening meal, and should be swallowed whole with a glass of water rather than being crushed or chewed. Taking the tablet at the same time each day helps maintain a consistent routine and supports more predictable protection against clot formation. Patients should never stop this medicine abruptly, particularly following a recent stent placement or cardiac event, without first consulting their doctor, as doing so can significantly increase the risk of clot formation within the treated blood vessel. If a dose is missed, it should be taken as soon as it is remembered, unless it is close to the time of the next scheduled dose, in which case it should simply be skipped rather than doubled.

Side Effects

Progrel-AP 75/75mg may cause side effects in some patients, given that it combines two medicines that both affect the blood’s clotting ability. Commonly reported effects include an increased tendency toward bruising, minor bleeding from cuts that takes longer than usual to stop, stomach discomfort, indigestion, and headache. Some patients may also experience diarrhea, joint pain, or changes in taste. In more serious but less common cases, symptoms such as blood in the stool or vomit, unusually dark stools, severe or persistent headache, or unexplained weakness may indicate internal bleeding and should prompt immediate medical attention. Allergic reactions, though uncommon, may present as skin rash, swelling, or difficulty breathing and also require urgent care. Because this combination increases the overall risk of bleeding compared to either medicine alone, patients should inform their doctor before any planned surgery or dental procedure, and any unusual or concerning symptoms should always be reported promptly.

Pregnancy & Breastfeeding

Progrel-AP 75/75mg is generally not recommended during the final trimester of pregnancy, and its use throughout pregnancy should only be considered if a doctor determines it to be clearly necessary, given the potential risks associated with both antiplatelet components. Women who are pregnant, believe they may be pregnant, or are planning to conceive should discuss the use of this medicine with their doctor before continuing or starting treatment. Both Clopidogrel and Aspirin may pass into breast milk in small amounts, so breastfeeding mothers should also consult their doctor before using this medicine to determine whether it is appropriate for their individual situation.

Storage Instructions

Progrel-AP 75/75mg tablets should be stored in a cool, dry place, away from direct sunlight, heat, and excess moisture. The tablets should be kept in their original blister packaging until they are ready to be used, and the medicine should always be stored well out of the reach and sight of children. Tablets should not be used once the expiry date printed on the packaging has passed.

FAQS

Q: Why are Clopidogrel and Aspirin often prescribed together instead of just one?
Combining these two antiplatelet medicines provides a stronger, more comprehensive protective effect against blood clot formation than either medicine alone, which is particularly important after events such as a heart attack or stent placement.

Q: Is it safe to stop taking this medicine before a dental procedure or surgery?
This should only be decided in consultation with a doctor, since stopping suddenly, especially soon after a stent placement, can significantly increase the risk of a dangerous clot forming.

Q: Why does this combination carry a higher bleeding risk than either medicine alone?
Because both Clopidogrel and Aspirin reduce the blood’s ability to clot, using them together has a stronger combined effect on bleeding tendency, which is why patients are monitored closely during treatment.

Q: What should be done if a dose is missed?
The missed dose should be taken as soon as it is remembered, unless it is close to the time of the next scheduled dose, in which case it should simply be skipped rather than doubled.

Disclaimer

Always use this medicine strictly according to your doctor’s instructions and prescribed dosage.